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Marina Babic, Christoforos Dimitropoulos, Quirin Hammer, Christina Stehle, Frederik Heinrich, Assel Sarsenbayeva, Almut Eisele, Pawel Durek, Mir-Farzin Mashreghi, Berislav Lisnic, Jacques Van Snick, Max Löhning, Simon Fillatreau, David R. Withers, Nicola Gagliani, Samuel Huber, Richard A. Flavell, Bojan Polic, Chiara Romagnani
NKG2D is a danger sensor expressed on different subsets of innate and adaptive lymphocytes. This study demonstrates how NKG2D enforces proinflammatory features of Th1 and Th17 cells and promotes inflammation in vivo, identifying NKG2D as an important target for the amelioration of Th1/ Th17-mediated inflammatory diseases.
Article
Jeffrey H. Lin, Austin P. Huffman, Max M. Wattenberg, David M. Walter, Erica L. Carpenter, David M. Feldser, Gregory L. Beatty, Emma E. Furth, Robert H. Vonderheide
Type 1 conventional dendritic cells are progressively and systemically dysregulated during pancreatic carcinogenesis, subject to semimaturation and IL-6–driven apoptosis. Yet, CD40 agonist synergizes with Flt3L to rescue cDC1 abundance and maturation, enabling a return to full CD8+ T cell priming.
Article
Qingxin Zhou, Meihua Lin, Xing Feng, Fei Ma, Yuekun Zhu, Xing Liu, Chao Qu, Hong Sui, Bei Sun, Anlong Zhu, Heng Zhang, He Huang, Zhi Gao, Yongxiang Zhao, Jiangyun Sun, Yuxian Bai, Junfei Jin, Xuehui Hong, Chang Zou, Zhiyong Zhang
Zhou et al. characterize a critical role of CLK3 on purine metabolism in cholangiocarcinoma (CCA). Overexpressed or mutated CLK3 promotes CCA progression in vitro and in vivo. Therefore, CLK3 may serve as a biomarker and potential drug target for CCA.
Article
Aneesha Dasgupta, Surendra K. Shukla, Enza Vernucci, Ryan J. King, Jaime Abrego, Scott E. Mulder, Nicholas J. Mullen, Gavin Graves, Kyla Buettner, Ravi Thakur, Divya Murthy, Kuldeep S. Attri, Dezhen Wang, Nina V. Chaika, Camila G. Pacheco, Ibha Rai, Dannielle D. Engle, Paul M. Grandgenett, Michael Punsoni, Bradley N. Reames, Melissa Teoh-Fitzgerald, Rebecca Oberley-Deegan, Fang Yu, Kelsey A. Klute, Michael A. Hollingsworth, Matthew C. Zimmerman, Kamiya Mehla, Junichi Sadoshima, David A. Tuveson, Pankaj K. Singh
This study demonstrates a novel signaling pathway regulating pancreatic cancer cachexia. These results establish that the Sirt1–Nox4 signaling axis plays an essential role in the manifestation of pancreatic cancer cachexia, and inhibition of this axis abrogates the cachexia syndrome.
Article
Ali Hussain, Veronique Voisin, Stephanie Poon, Christina Karamboulas, Ngoc Hoang Bao Bui, Jalna Meens, Julia Dmytryshyn, Victor W. Ho, Kwan Ho Tang, Joshua Paterson, Blaise A. Clarke, Marcus Q. Bernardini, Gary D. Bader, Benjamin G. Neel, Laurie E. Ailles
In this study, Hussain et al. demonstrate that cancer-associated fibroblasts (CAFs) in high-grade serous ovarian cancer are heterogeneous, that CAF state drives cancer aggressiveness and patient outcomes, and that TCF21 is a master regulator of CAF state.
Brief Definitive Report
Sohinee Bhattacharyya, Chet Oon, Aayush Kothari, Wesley Horton, Jason Link, Rosalie C. Sears, Mara H. Sherman
Here Bhattacharyya et al. show that MYC is a molecular point of convergence for microenvironmental and cell-autonomous signals in RAS-transformed pancreatic cancer cells. They identify cancer-associated fibroblast–derived FGF1 as a critical paracrine regulator of MYC, and a novel link between the pancreatic tumor microenvironment and oncogenic transcription.
Brief Definitive Report
Georgina Bowyer, Hannah Sharpe, Navin Venkatraman, Pierre Birahim Ndiaye, Djibril Wade, Nicole Brenner, Alex Mentzer, Catherine Mair, Tim Waterboer, Teresa Lambe, Tandakha Dieye, Souleymane Mboup, Adrian V.S. Hill, Katie J. Ewer
CMV is emerging as a key driver of immunosenescence. Bowyer et al. report that an expansion of phenotypically senescent CD4+ and CD8+ T cells is associated with reduced responses to Ebola vaccines ChAd3–EBO-Z and MVA–EBO-Z in young UK and Senegalese adults.

Related Articles from Rockefeller University Press

Current Issue
Volume 217,
Issue 5,
May 4, 2020
Reviews & Opinions
Viewpoint
Carolina Magdalen Greco, Paolo Sassone-Corsi
Personalized medicine and circadian rhythms: Opportunities for modern society
Insights
Luc Van Kaer, Sebastian Joyce
The Hippo signaling pathway controls the maturation and effector differentiation of iNKT cells.
Perspective
Santosha A. Vardhana, Jedd D. Wolchok
This Perspective explores the contributions of the innate and adaptive immune systems to both viral control as well as toxicity during COVID-19 infections and offers suggestions to both understand and therapeutically modulate anti-COVID immunity.

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